SARS-CoV-2 maturation driven by a mechano-active nucleocapsid-RNA condensate
Rini Ravindran, Benjamin Guerin, Ahmad Mahmood, Sherry S.W. Leung, Haytham M. Wahba, Pierre Dagenais, Kaushal Baid, Sauhard Shrivastava, Arkadeb Bhuinya, Sydney Williams, Alisa Sandolache, Pascale Legault, James G. Omichinski, Arinjay Banerjee, Paul W. Wiseman, , Stephen W. Michnick
This study shows that SARS-CoV-2 maturation involves N protein-vgRNA condensates that are selectively enveloped by membranes due to RNA-dependent material properties.
bioRxiv · Sep 18, 2026 · PreprintBiophysics