Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics
Kristof A. Torkenczy, Lucas Charles Reineke, Sean W. Dooling, Benjamin Henderson, Daniel N. Itzhak, Benjamin A. Yang, Dongze He, R Myers, Peter Walter, Stefka Tyanova, Mauro Costa‐Mattioli
The paper generates a single-cell ISR atlas in a mouse model of persistent ISR activation, identifying cell-type-specific ISR programs and their roles in cognitive decline.
bioRxiv · Feb 28, 2025 · PreprintNeuroscience