Early-onset spontaneous murine mammary tumors show increased lymphocyte representation and reduced MHC antigen presentation
Ryann R Ray, Lisa Polin, Rui Geng, Benjamin Kidder, Jennifer B. Jacob
This study shows that introducing the PWK/PhJ genetic background in HER2/neu-driven breast cancer mice leads to earlier tumor onset, increased immune cell presence, and reduced MHC antigen presentation.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology