Single-chain nanobody inhibition of Notch and avidity enhancement utilizing the β-pore forming toxin Aerolysin
Andrew C.D. Lemmex, Jeremy R. Allred, Jason Ostergaard, Jake Trask, Hannah N. Bui, Michael J. M. Anderson, Benjamin Kopp, Oakley Streeter, Adam T. Smiley, Natalia S. Babilonia-Díaz, Bruce R. Blazar, LeeAnn Higgins, Peter M. Gordon, Joseph M. Muretta, Wendy Ryan Gordon
This study develops a Notch inhibitory nanobody and demonstrates a strategy to enhance its efficacy through fusion with an Aerolysin domain.
ACS Chemical Biology · Mar 13, 2025Peer-reviewedBiochemistry