ABCB1-Mediated Drug Efflux Drives Resistance to VpreB1-Targeted Antibody-Drug Conjugates in B-cell Lymphoblastic Leukemia
Robin L. Williams, Xiaohong Wang, Jason Ostergaard, Jongseok Kang, Madison Gohman, Luke Lambert, Timothy P. Singleton, Sarah Kathleen Tasian, Megan V. Hilgers, Keegan C Lee, Joseph M. Muretta, Stuart S. Winter, Peter M. Gordon
This study identifies ABCB1-mediated drug efflux as a mechanism of resistance to VpreB1-targeted antibody-drug conjugates in B-cell lymphoblastic leukemia and suggests strategies to overcome this resistance.
bioRxiv · Aug 26, 2026 · PreprintCancer Biology