Architecture of a multi-cellular polygenic network governing immune homeostasis
Tania Dubovik, Elina Starosvetsky, Benjamin LeRoy, Rachelly Normand, Yasmin Admon, Ayelet Alpert, Yishai Ofran, Max G’Sell, Shai S. Shen-Orr
The paper identifies a polygenic network governing immune homeostasis using mass-cytometry data from 55 mouse strains, showing 52% of trait genes predict phenotype and revealing multi-cellular regulatory complexity.
bioRxiv · Sep 23, 2018 · PreprintGenetics