Perturbation-based propagation of bacterial composition uncertainty improves robustness and reproducibility of microbiome differential abundance analysis.
Madison E Andrews, Tessa Vincennie, Milica Koprivica, Mackenzie Browning, Steven Bracco, Michael Mullan, Aaron Wright, Fiona Crawford, Benoit Mouzon
PARALLAX improves microbiome differential abundance analysis by addressing compositional data, uncertainty, and experimental design through a unified framework with stability-based metrics.
bioRxiv · Oct 27, 2026 · PreprintBioinformatics