Loss of dihydroceramide desaturase drives neurodegeneration by disrupting endoplasmic reticulum and lipid droplet homeostasis in glial cells
Yuqing Zhu, Kevin Cho, Haluk Lacin, Yi Zhun Zhu, Jose T DiPaola, Beth A. Wilson, Gary J. Patti, James B. Skeath
This study shows that loss of dihydroceramide desaturase in glial cells causes neurodegeneration by disrupting ER and lipid droplet homeostasis, leading to neuronal death and developmental defects.
eLife · Aug 27, 2025Peer-reviewedDevelopmental Biology