Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase
Jacquelyn R. Roberts, Yasuhiro Horibata, Frank E. Kwarcinski, Vinson Lam, Ashleigh M. Raczkowski, Akane Hubbard, Betsy White, Hiroyuki Sugimoto, Gregory G. Tall, Melanie D. Ohi, Shoji Maeda
The paper presents the structure of yeast CPT1 in multiple substrate-bound states to elucidate the mechanism of phospholipid synthesis and selectivity.
Nature Communications · Jan 2, 2025Peer-reviewedBiochemistry