Genetic association of primary non-response to Anti-TNFα therapy in patients with Inflammatory Bowel Disease
Tanima De, Honghong Zhang, Cristina Alarcon, Bianca Lec, Juan Avitia, Erin Smithberger, Chuyu Chen, Minnie Horvath, Sara Kwan, Mary Young, Sarbani Adhikari, John Kwon, Jennifer Pacheco, Gail Pairitz Jarvik, Wei-Qi Wei, , Minoli A. Perera
This paper identifies a genetic variant associated with primary non-response to anti-TNFα therapy in IBD patients and links it to increased TNF secretion through autophagy mechanisms.
Pharmacogenetics and Genomics · Aug 12, 2021Peer-reviewedGenetic & Genomic Medicine