Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
Mary E. McMahon, Steve Lianoglou, Sridhar Narayan, Jiacheng Zhang, Shilin Chen, Jinxing Li, William Kluwe, Yang Liu, Bin Cao, Jie Luo, Jijun Chen, Xiaojin Zhang, Sizhu Lu, Melanie Das, Anil C. Nair, , Paul R. August
RTX-117, a clinical stage eIF2B activator, blunts chronic ISR activation and improves nerve and motor function in a mouse model of Charcot-Marie-Tooth Disease Type 2D.
bioRxiv · Aug 6, 2026 · PreprintCell Biology