EPAS1 regulates host antibacterial defense in response to bacterial quorum sensing
Heng Li, Xiaohan Kong, Binbin Cui, Xiaohui Li, Xia Li, Mingfang Wang, Liu-En Wang, Xiayu Chen, Wei Qian, Lian‐Hui Zhang, Yongliang Zhang, Yinyue Deng
This study shows EPAS1 acts as an intracellular receptor for bacterial quorum sensing signals, enhancing antibacterial defense by promoting cytokine production and improving survival in infected mice.
bioRxiv · Oct 9, 2025 · PreprintMicrobiology