Author

Binfan Chen

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Sidi CheniD· 3 shared Bo Tao· 2 shared Jiang YuiD· 2 shared Jiangbing ZhouiD· 2 shared Rong FaniD· 2 shared Aleksandra IvoviciD· 1 shared Alev BaysoyiD· 1 shared Anthony A. FungiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPathology

Sidi ChenORCID

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Author profile →

3 papers

Recent·Most cited

Spatial Glyco-Codes Define Human Liver Pathology and Progression

Xiaolong Tian, Anthony A. Fung, Xingbo Shang, Dingyao Zhang, Binfan Chen, Lei Zhang, K E X I N Li, Mei Zhong, Yifan Deng, Mingyu Yang, Yao Lu, Bo Tao, Fu Gao, Alev Baysoy, Xiao Louise Lin, , Rong Fan

This study introduces spatial-GPT, a platform for spatial glycan, protein, and transcriptome profiling in human liver tissues, revealing glyco-codes that define disease states and progression.

bioRxiv · Jul 12, 2026 · PreprintPathology

CAR-T-drug conjugate against solid tumor

Shan Xin, Yanzhi Feng, Feifei Zhang, Jiang Yu, Chuanpeng Dong, Bo Tao, Kaiyuan Tang, Qihao Wu, Binfan Chen, Ping Ren, Nipun Verma, Chuan Liu, Kazushi Suzuki, Xinyu Ling, Daniel Park, , Sidi Chen

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

bioRxiv · Jan 2, 2026 · PreprintImmunology

Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome

Xiaona Lu, Ying Xie, Youmei Bao, Jiang Yu, Zefeng Wang, Jiali Fan, Wendy C. Sheu, Gretchen Long, Zewei Tu, Jie Tong, Garret Manquen, Yichao Li, Varun Katta, Ryan Dz-Wei Chow, Binfan Chen, , Jiangbing Zhou

This paper develops a non-viral genome-editing method called STEP-RNPs that effectively treats Angelman syndrome in mice and human neurons, showing functional genetic rescue without off-target effects.

bioRxiv · Nov 13, 2025 · PreprintGenetics