Lysosomal Glycosaminoglycan Catabolism Regulates Microglial Cell State in the Developing CNS
Keenan T. Hope, Yiwen Zhang, Amrita Basu, Bingmin Luo, Kaleb Chassie, Ryan J. Weiss, Dhananjay Yellajoshyula
This study shows that lysosomal glycosaminoglycan catabolism in microglia regulates their cell state during CNS development, linking ECM remodeling to microglial identity.
bioRxiv · Oct 13, 2026 · PreprintNeuroscience