Neural RNA splicing models rely on reading frame information unavailable to the splicing machinery
Kavi Gupta, Bixuan Wang, Phillip A Sharp, Christopher B Burge, Armando Solar-Lezama
The paper shows that neural RNA splicing models rely on reading frame information that the splicing machinery cannot access, leading to errors in predicting poison exons.
bioRxiv · Nov 4, 2026 · PreprintBioinformatics