Impaired microglial phagocytosis promotes seizure development
Dale B. Bosco, Václav Křemen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A. Ebner, Jiaying Zheng, Manling Xie, Aastha Dheer, Jadyn F. Perry, Abhijeet S. Barath, Aivi T. Nguyen, Gregory A. Worrell, Long‐Jun Wu
The paper shows that impaired microglial phagocytosis due to TREM2 deficiency promotes seizure development in mice and correlates with seizure history in human patients.
Brain, Behavior, and Immunity · Jan 1, 2025Peer-reviewedNeuroscience