Mild activation of the mitochondrial unfolded protein response increases lifespan without increasing resistance to stress
Alexa Di Pede, Bokang Ko, Abdelrahman AlOkda, Aura A Tamez González, Shusen Zhu, Jeremy M. Van Raamsdonk
This study shows that mild activation of the mitochondrial unfolded protein response (mitoUPR) through ATFS-1 can increase lifespan without enhancing stress resistance in worms.
Open Biology · Apr 1, 2025Peer-reviewedDevelopmental Biology