Thousandfold Expansion Microscopy
Helena Hu, Donatus Krah, Antonios Ntolkeras, Sushovan Chanda, Alina Heimbrodt, Milton Mondal, Jonas Altendorf, Bowen Jing, Bonnie Berger, Ali Shaib, Silvio O. Rizzoli, Edward S. Boyden
A four-network sodium acrylate/dimethylacrylamide hydrogel, cast ionic-within-ionic without neutral re-embedding, reaches about 1000-fold linear expansion and resolves individual peptide residues on standard confocal microscopes.
bioRxiv · Jul 21, 2026 · PreprintMolecular Biology✦ In-depth digest