Mechanism of NPC1L1 mediated 27-hydroxycholesterol metabolisms in the occurrence and development of osteoporosis
Bohao Li, Zhicheng Lv, Boyu Chen, Tieqi Zhang, Yueming Yu, Shiwei Sun, Haitian Huang, Lei Zhou, Minghai Wang
This study shows NPC1L1 inhibits osteogenesis and promotes osteoporosis by regulating cholesterol metabolism through the C/EBP/Cyp27a1/27-OHC axis.
bioRxiv · Sep 30, 2024 · PreprintMolecular Biology