A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner, Shan Sun, Rui Liang, Miguel Foronda, Emma M. Schatoff, Elizabeth Granowsky, Sukanya Goswami, Alyna Katti, Benjamin I. Leach, Heather L. Alcorn, Tuomas Tammela, Yoshiyuki Fukase, Tanweer A. Khan, , Lukas E. Dow
The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.
bioRxiv · Mar 4, 2025 · PreprintCancer Biology