Cancer BiologybioRxivPreprint
Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC
Salvador Alonso, Kevan Chu, Marie J. Parsons…·Lukas E. Dow
This study identifies genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC using single-cell spatial transcriptomics and exome sequencing, revealing inflammatory and fetal-like transcriptional signatures associated with resistance.
4 citations