Towards Quantitative In Vitro Modelling of Focused Ultrasound-mediated Blood-Brain Barrier Opening using an Ultrasound-transparent Organ-on-Chip Device
Nabhan M. Fakrudin, Nathan Han, Laith Kabbani, Brandon Lan, Suzan Aldekr, Baiju Thomas, Matthew W. Barrett, Rayna J. Gonzales, Frédéric Zenhausern, Jian Gu
This study develops an ultrasound-transparent organ-on-chip device to quantitatively model FUS-mediated BBB opening and assess the effects of acoustic exposure and bubble activity.
bioRxiv · Sep 30, 2026 · PreprintBioengineering