Rayna J. Gonzales

This study develops an ultrasound-transparent organ-on-chip device to quantitatively model FUS-mediated BBB opening and assess the effects of acoustic exposure and bubble activity.

This study examines changes in S1PR expression and endothelial barrier/inflammatory markers in human brain endothelial cells after ischemia-reperfusion injury, finding increased S1PR1 expression and potential therapeutic implications.

This study shows that inhibiting LOX-1 and MMP-9 with drugs improves outcomes after delayed rt-PA treatment in stroke by reducing hemorrhage and edema.

This study investigates how oxLDL via LOX-1 affects vascular reactivity, stiffness, and remodeling in mouse thoracic aortas, revealing sex, age, and endothelial cell-dependent differences.

This study shows that selective S1PR1 activation reduces brain infarct volume and improves neurological outcomes in mice after stroke, while also enhancing endothelial cell survival under hypoxic conditions.

This study investigates the long-term cognitive and cerebrovascular effects of mild traumatic brain injury in rats, finding chronic cognitive dysfunction and altered vascular reactivity.