DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required
Brian K. Wilson, Lucas D. Johnson, Jason Liu…·Kurt D. Ristroph
This study shows that DSPE-PEG fails to retain mAbs on LNPs in vivo, while a higher molecular weight PCL-b-PEG anchor maintains stability, highlighting the importance of anchoring strength for extrahepatic delivery.