Accurate single-bead force calibration in high-throughput magnetic tweezers reveals the mechanism of directional transcription termination by MTERF1
Pim P. B. America, Eugeniu Ostrofet, Britney Johnson, Salina Quack, Flavia Papini, Quinte Smitskamp, Daniel Buc, Jamie J. Arnold, Craig E. Cameron, David Dulin
This paper develops an in-situ force calibration method for magnetic tweezers and uses it to reveal how MTERF1 causes directional transcription termination through DNA unwinding and a kinetic barrier.
bioRxiv · Apr 21, 2026 · PreprintBiophysics