Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport
Jason A. Wojcechowskyj, Robyn M. Jong, Imre Mäger, Britta Flach, Paul V. Munson, Progya P Mukherjee, Barbara Mertins, Katherine R Barcay, Thomas Folliard
This study shows that RNAx, a leader-protein-encoding mRNA, reduces reactogenicity while maintaining immunogenicity in saRNA-LNP vaccines.
npj Vaccines · Apr 29, 2025Peer-reviewedImmunology