The alternative splicing generated muscle-specific MEF2D2 isoform promotes muscle ketolysis and running capacity in mice
Sushil Kumar, Hina Iqbal, Guan Xiangnan, Brittany Mis, Devanshi D. Dave, Suresh Kumar, Jacob Besler, Ranjan Dash, Zheng Xia, Ravi Kumar Singh
This study identifies a muscle-specific MEF2D2 isoform that enhances ketone body utilization and running capacity in mice by regulating ketolytic gene expression.
bioRxiv · May 22, 2023 · PreprintMolecular Biology