Shikonin alleviates bone cancer pain through suppression of spinal IGF2-associated p38 MAPK signaling
zhenghang Ma, Jin Jia, Dashan Lu, Yu Wanying, Huang Xiaogeng, Zhang Shuyao, Fan Xinfang, Zhang Jing, Bu Fan, Xu Longsheng, Yao Ming
This study shows that intrathecal Shikonin reduces bone cancer pain in rats by suppressing spinal IGF2-associated p38 MAPK signaling, improving pain-related behaviors and reducing inflammation.
bioRxiv · Nov 7, 2026 · PreprintNeuroscience