Modelling metastasis in zebrafish unveils regulatory interactions of cancer-associated fibroblasts with circulating tumour cells
P. Hurtado, I. Martinez-Pena, S. Yepes-Rodriguez, M. Bascoy-Otero, C. Abuin, C. Fernandez-Santiago, L. Sanchez, R. Lopez-Lopez, R. Pineiro
This study uses zebrafish to model interactions between circulating tumour cells and cancer-associated fibroblasts, showing that physical clustering enhances CTC survival and proliferation through paracrine signaling.
Frontiers in Cell and Developmental Biology · Mar 6, 2023Peer-reviewedCancer Biology