Author

C. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Microbiology· 3 Cell Biology· 1 Immunology· 1 Pathology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Organism:human· 7 Research Focus:cell type annotation· 6 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

J.-C. Sirard· 2 shared J.-W. Veening· 2 shared M. Baldry· 2 shared X. Liu· 2 shared A. B. Davila-Ibanez· 1 shared A. Barros· 1 shared A. C. Faber· 1 shared A. Domenech· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

J.-C. Sirard

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

ATP citrate lyase is an essential player of the metabolic rewiring induced by PTEN loss during T-ALL development.

G. Andrieu, G. Hypolite, E. Balducci, C. Costa, E. Verhoeyen, I. Nemazanyy, G. Panasyuk, K. Wellen, E. Macintyre, V. Asnafi, M. Tesio

This study identifies ATP citrate lyase (ACLY) as a critical metabolic driver in PTEN-deficient T-ALL, showing its essential role in disease progression and therapeutic targeting potential.

bioRxiv · Mar 27, 2023Cancer Biology

Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

V. Minhas, A. Domenech, D. Synefiaridou, D. Straume, M. Brendel, G. Cebrero, X. Liu, C. Costa, M. Baldry, J.-C. Sirard, C. Perez, N. Gisch, S. Hammerschmidt, L. S. Havarstein, J.-W. Veening

This study shows that competence in Streptococcus pneumoniae is crucial for virulence by increasing surface exposure of virulence factors and providing resistance to fratricide.

bioRxiv · Aug 3, 2022 · PreprintMicrobiology

Pathogenicity of novel Monosporascus species in accessions of four melon botanical groups

C. Costa, A. M. Paiva Negreiros, R. Sales, G. Nunes

This study evaluates the pathogenicity of five newly described Monosporascus species compared to M. cannonballus on melon accessions from four botanical groups, identifying virulent species and resistant accessions.

bioRxiv · Jul 28, 2022 · PreprintPlant Biology

Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models

S. Jacob, T. H. Turner, J. Cai, K. V. Floros, A. K. Yu, C. M. Coon, R. Khatri, M. A. Alzubi, C. T. Jakubik, Y. M. Bouck, M. Puchalapalli, M. Shende, M. G. Dozmorov, S. Boikos, B. Hu, , A. C. Faber

The paper identifies UBA1 as a druggable target in c-MYC-high TNBC models, showing TAK-243 induces ER-stress and apoptosis in vitro and in vivo.

bioRxiv · May 17, 2022Cancer Biology

Red blood cells protein profile is modified in breast cancer patients

T. Pereira-Viega, S. B. Bravo, A. Gomez-Tato, C. Yanez-Gomez, C. Abuin, V. Varela, J. Cueva, P. Palacios, A. B. Davila-Ibanez, R. Pineiro, A. Vilar, M. P. Chantada-Vazquez, R. Lopez-Lopez, C. Costa

The paper characterizes the proteomic profile of red blood cells in breast cancer patients and identifies LAMP2 as a potential diagnostic and prognostic marker.

bioRxiv · Jan 4, 2022Cancer Biology

Peroxisome-derived hydrogen peroxide can modulate the sulfenylation profiles of key redox signaling proteins

C. Lismont, I. Revenco, H. Li, C. Costa, L. Lenaerts, M. Hussein, J. De Bie, B. Knoops, P. P. Van Veldhoven, R. Derua, M. Fransen

This study identifies peroxisome-derived H2O2 targets and shows their sulfenylation kinetics vary across compartments and protein families.

bioRxiv · Oct 8, 2021Cell Biology

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

L. Dewachter, X. Liu, J. Denereaz, V. de Bakker, C. Costa, M. Baldry, J.-C. Sirard, J.-W. Veening

This paper identifies the mevalonate pathway as a target to resensitize amoxicillin-resistant Streptococcus pneumoniae using sCRilecs-seq.

bioRxiv · Sep 13, 2021Microbiology

Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

A. Stewart, E. Sinclair, J. C. Ng, F. Fraternali, J. Silvia-O'Hare, A. Page, I. Serangeli, C. Margreitter, N. Kasar, K. Longman, C. Frampas, H.-M. Lewis, C. Costa, B. Wu, D. Kipling, , D. Dunn-Walters

The paper analyzes B cell repertoires from SARS-CoV-2, Ebola, and RSV infections to identify distinct anti-viral immune responses and repertoire characteristics.

bioRxiv · Aug 19, 2021Immunology

The loss of the pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion

J. Gonzalez, M. Salvador, O. Ozkayab, M. Spick, C. Costa, M. J. Bailey, C. Avignone Rossa, R. Kuemmerli, J. I. Jimenez

This study shows that deleting the pyoverdine secondary receptor FpvB in Pseudomonas aeruginosa creates a fitter strain that outcompetes wildtype in structured environments under antibiotic stress.

bioRxiv · May 8, 2020Microbiology

Comparison Between Normobaric Hypoxia Altitude Simulation Test and Altitude Hypoxia Predictive Equations in Cystic Fibrosis Patients

C. Costa, A. Barros, J. V. Rodrigues, R. Staats, M. Alves, P. Cardim, C. Lopes, C. Barbara, L. Moita, S. Moreira

The paper compares normobaric hypoxia altitude simulation test results with five predictive equations in cystic fibrosis patients to assess their accuracy in predicting in-flight hypoxia.

bioRxiv · Mar 9, 2019 · PreprintPathology