SARS-CoV-2 infection suppresses ACE2 function and antiviral immune response in the upper respiratory tract of infected patients
L. Gutierrez-Chamorro, E. Riveira-Munoz, C. Barrios, V. Palau, M. Massanella, E. Garcia-Vidal, R. Badia, S. Pedreno, J. Senserrich, E. Rodriguez, B. Clotet, C. Cabrera, O. Mitja, M. Crespo, J. Pascual, , E. Ballana
This study shows SARS-CoV-2 reduces ACE2 activity and antiviral gene expression in the upper respiratory tract, while initially increasing interferon-stimulated genes.
bioRxiv · Nov 18, 2020 · PreprintImmunology