SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
P. Demange, E. Joly, J. Marcoux, P. R. A. Zanon, D. Listunov, P. Rulliere, C. Barthes, C. Noirot, J.-B. Izquierdo, K. Pradines, R. Hee, M. V. de Brito, M. Marcellin, R.-F. Serre, O. Bouchez, , S. Britton
The paper identifies SDR enzymes as bioactivators of lipidic alkynylcarbinols, converting them into cytotoxic electrophiles that modify proteins and induce cell death.
bioRxiv · Sep 15, 2021Biochemistry