Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner
C. S. Johnson, K. Sham, S. Belluschi, X. Wang, W. Lau, K. B. Kaufmann, G. Krivdova, E. F. Calderbank, N. Mende, J. McLeod, G. Mantica, M. J. Williams, C. Grey-Wilson, M. Drakopoulos, S. Sinha, , E. Laurenti
This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.
bioRxiv · Nov 17, 2022 · PreprintCell Biology