B. Gottgens

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

This study shows autophagy compensates for inflammation-induced metabolic issues in old HSCs, and temporarily boosting autophagy can restore their function.

Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

This study identifies Sema4A as a critical niche factor required for myeloid-biased HSC self-renewal and long-term persistence under stress.

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

This study identifies Rxfp4-expressing hypothalamic neurons as regulators of food intake and preference in mice through genetic and pharmacological manipulations.

Stromal inflammation is a targetable driver of hematopoietic aging

This study identifies stromal inflammation as a key driver of hematopoietic aging and shows that blocking IL-1 signaling can improve hematopoietic regeneration.

Analysis of phloem trajectory links tissue maturation to cell specialization.

The paper reconstructs the protophloem developmental trajectory in Arabidopsis root cells to show how maturation gradients and transcription factors regulate cell specialization.

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes

This study compares HSPC landscapes in bone marrow, spleen, and peripheral blood using single-cell RNA-seq, revealing distinct molecular and functional differences in haematopoiesis across these sites.

Single-cell molecular profiling provides a high-resolution map of basophil and mast cell differentiation

This study maps basophil and mast cell differentiation using single-cell RNA sequencing and flow cytometry in mice, revealing distinct trajectories and lineage-specific gene regulation.

Malaria-induced remodelling of the bone marrow microenvironment mediates loss of haematopoietic stem cell function

This study investigates how malaria infection alters the bone marrow microenvironment, leading to impaired haematopoietic stem cell function through changes in endothelium and osteoblasts.