X. Wang

Diffusing protein binders to intrinsically disordered proteins

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia

This study identifies impaired vascular endothelial integrity in skeletal muscle as a driver of cancer cachexia and shows that restoring endothelial PGC1 can prevent muscle loss.

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction

This study shows that human ANP32A/B are SUMOylated, enabling avian influenza virus NS2 to enhance polymerase activity and overcome species-specific restrictions.

The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth

The study identifies 20 cell types in Arabidopsis root secondary growth using single-cell RNA sequencing and lineage tracing, revealing dynamic parenchyma cell diversity and functional roles.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

Antimicrobial Profile from Frog Skin Peptides

This study evaluates the antimicrobial efficacy of frog skin peptides against bacteria and fungi, finding Magainin 2 and Bombesin effective against Bacillus subtilis, Escherichia coli, and Trichoderma harzianum.

Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

This study identifies microbial pseudomorphs as the earliest three-dimensional body fossils of segmented bilaterians from the basal Cambrian, revealing a diversified bilaterian world.

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

This study shows autophagy compensates for inflammation-induced metabolic issues in old HSCs, and temporarily boosting autophagy can restore their function.

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

PIP-Seq identifies novel heterogeneous lung innate lymphocyte population activation after combustion product exposure

The paper introduces PIP-Seq to study lung ILC activation after exposure to environmental toxins, identifying novel ILC subsets and activation pathways.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

Resolving human α versus β cell fate allocation for the generation of stem cell-derived islets

The paper investigates human α and β cell fate allocation in stem cell-derived islets, revealing a distinct regulatory mechanism compared to mice and identifying pharmacological strategies to enhance cell fate commitment.

The translocation assembly module (TAM) catalyzes the assembly of bacterial outer membrane proteins in vitro

This study shows that the TAM complex catalyzes the assembly of bacterial outer membrane proteins in vitro, similar to the BAM complex, and identifies the necessity of TamA and TamB for its activity.

Cell fate plasticity of xylem-pole-pericycle in Arabidopsis roots

This study investigates the cell fate plasticity of xylem-pole-pericycle cells in Arabidopsis roots, showing how auxin and cytokinins regulate their ability to form lateral roots or contribute to cambium.

Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex

This study determines the structure of the AP5:SPG11-SPG15 complex and shows it binds PI3P, senses membrane curvature, and drives membrane remodeling in vitro.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

Multispectral live-cell imaging with uncompromised spatiotemporal resolution

The paper introduces a multispectral imaging approach for live-cell imaging, enabling accurate unmixing of low signal-to-noise ratio data at video rates.

Vasoactive Intestinal Peptide Amphiphile Micelle Material Properties Influence Their Cell Association and Internalization

This study investigates how VIP amphiphile micelle properties affect macrophage association, finding that VPAC targeting enhances binding while shape and size influence long-term association.

Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1

This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

Adjuvant Delivery Method and Nanoparticle Charge Influence Peptide Amphiphile Micelle Vaccine Bioactivity

This study investigates how adjuvant delivery methods and nanoparticle charge affect the bioactivity of peptide amphiphile micelle vaccines, showing improved dendritic cell activation with electrostatic complexation.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from individuals exposed only to ancestral SARS-CoV-2.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.