Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice
J. N. Borgerding, J. Shang, G. J. Britton, H. Salmon, C. Bigenwald, B. Maier, S. R. Rose, I. J. Mogno, A. O. Kamphorst, M. Merad, J. J. Faith
The paper shows that human microbial transplants can restore T cell cytotoxicity and anti-tumor response to PD-L1 blockade in gnotobiotic mice by altering immune cell infiltration and gene expression.
bioRxiv · Aug 7, 2020 · PreprintImmunology