Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations
C. Tiezzi, A. Vecchi, M. Rossi, D. Cavazzini, A. Bolchi, D. Laccabue, L. Sacchelli, F. Brillo, T. Meschi, A. Ticinesi, A. Nouvenne, G. Donofrio, P. Zanelli, M. Benecchi, S. Giuliodori, , C. Boni
The paper shows that SARS-CoV-2 mutations can create new CD8 T cell epitopes, enhancing immune responses in some individuals with weak CD8 T cell reactivity.
bioRxiv · Oct 28, 2022Immunology