M. Rossi

The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.

The paper introduces a comprehensive variant benchmark set derived from a high-quality diploid assembly, improving small and structural variant detection across complex genomic regions.

Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis

The paper reports the yerba mate genome, identifies a unique caffeine biosynthesis pathway, and reveals structural adaptations for convergent evolution of caffeine production.

Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother's milk

This study links the infant gut microbiome and resistome to bacterial strains in mother's milk using metagenomic samples from mother-infant pairs.

M1-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis in a hyper-glucose environment

This study shows that high-glucose-treated macrophage-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis, inducing insulin resistance or hyper-phosphorylation depending on glucose concentration.

Adaptive introgression of a visual preference gene

The paper shows two Heliconius butterfly species evolved similar visual mating preferences through hybridization, linking a gene to behavior.

Ubiquitination is a novel post-translational modification of VMP1 in autophagy of human tumor cells

This study identifies ubiquitination as a novel post-translational modification of VMP1 during autophagy in human tumor cells, which contributes to therapy resistance.

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.

Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations

The paper shows that SARS-CoV-2 mutations can create new CD8 T cell epitopes, enhancing immune responses in some individuals with weak CD8 T cell reactivity.

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

This study investigates BAFF's role in senescence by showing its cell-type-specific effects on SASP and growth arrest.

Auxin-driven ecophysiological diversification of leaves in domesticated tomato

The paper identifies a single-nucleotide polymorphism in an auxin-related transcription factor that controls the distribution of heterobaric and homobaric leaves in tomatoes.

Shade-induced WRKY transcription factors restrict root growth during the shade avoidance response

The paper identifies WRKY transcription factors and ethylene signaling as key regulators of root growth repression during the shade avoidance response in Arabidopsis and tomato.

Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease

This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.

One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration.

The paper shows that the C-terminal fragment of the M2 muscarinic receptor localizes to mitochondria and regulates cell respiration, independent of its canonical GPCR function.

Larval nutrition impacts survival to adulthood, body size, and the allometric scaling of metabolic rate in adult honeybees

This study shows that larval diet quality in honeybees affects adult survival, body size, and the allometric scaling of metabolic rate.

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.

Metronomic therapy prevents emergence of drug resistance by maintaining the dynamic of intratumor heterogeneity.

This study shows metronomic therapy better controls tumor heterogeneity than maximum-tolerated dose by leveraging drug-sensitive clones' suppressive effect on resistant ones through paracrine mechanisms.

HERC1 regulates breast cancer cells migration and invasion

This study identifies HERC1 as a regulator of breast cancer cell migration and invasion, showing its potential as a therapeutic target.

How Euglena gracilis swims: flow field reconstruction and analysis

This paper reconstructs and analyzes the three-dimensional flow fields generated by Euglena gracilis swimming, validating a synthetic stroke model through numerical simulations and singularities.

Silencing of ATP synthase β reduces phytoplasma multiplication in the leafhopper vector Euscelidius variegatus

This study silences ATP synthase β in leafhopper vectors and shows reduced phytoplasma multiplication.

THE REGULATORY EFFECT OF LIGHT OVER FRUIT DEVELOPMENT AND RIPENING IS MEDIATED BY EPIGENETIC MECHANISMS

This study identifies PHYB1 and PHYB2 as regulators of DNA methylation during tomato fruit development and ripening through integrative methylome, siRNAome, and transcriptome analyses.

A new model of chronic Mycobacterium abscessus lung infection in immunocompetent mice

This study develops a new murine model of chronic Mycobacterium abscessus lung infection and demonstrates its ability to sustain infection and be monitored with MRI.

USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer

This study identifies USP19 as a regulator of cancer cell migration and invasion, showing its role as a prognostic marker in early breast cancer.

Neural divergence and hybrid disruption between ecologically isolated Heliconius butterflies

This study shows that neural divergence and hybrid disruption occur in Heliconius butterflies due to environmental transitions, contributing to reproductive isolation.

Biological characterization of Euscelidius variegatus iflavirus 1

This study characterizes the transmission and biology of EVV-1, an iflavirus in Euscelidius variegatus, showing both vertical and horizontal transmission and its systemic presence in host life stages.

Visual mate preference evolution during butterfly speciation is linked to neural processing genes

The paper identifies genes linked to visual mate preference divergence in Heliconius butterflies through QTL analysis and gene expression studies in neural tissues.

Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules

This study shows Malpighamoeba infection increases fluid secretion and reduces P-glycoprotein detoxification efficiency in locust Malpighian tubules, potentially affecting insect survival.

Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells via modulating metabolism and death pathways.

This study shows that low ANT1 expression in rhabdomyosarcoma cells promotes oncogenic properties by altering metabolism and death pathways, and restoring ANT1 sensitizes cells to chemotherapy.

P-glycoprotein Detoxification by the Malpighian Tubules of the Desert Locust

This study investigates P-glycoprotein function in desert locust Malpighian tubules, showing their role in detoxification through substrate extrusion and fluid secretion.

Genetics behind the biosynthesis of nonulosonic acid containing lipooligosaccharides in Campylobacter coli

This study identifies the role of CstIV and CstV in C. coli lipooligosaccharide biosynthesis, showing cstV is involved in sialylation and cstIV in adding a diacetylated nonulosonic acid residue.

The ULK1-FBXW5-SEC23B nexus controls autophagy

This study identifies the ULK1-FBXW5-SEC23B pathway as a regulator of autophagy by controlling COPII localization and SEC23B stability during nutrient starvation.