Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18
N. Iyer, M. Grizotte-Lake, S. R. Gordon, A. C. S. Palmer, C. Calvin, S. Vaishnava
This study shows that vitamin A signaling in intestinal epithelial cells enhances resistance to Salmonella infection by promoting IL-18 production, which drives epithelial cell shedding and immune cell IFN-gamma production.
bioRxiv · Jun 12, 2019Immunology