Protein design under competition for amino acids availability
F. Nerattini, L. Tubiana, C. Cardelli, V. Bianco, C. Dellago, I. Coluzza
This study designs proteins with reduced amino acid alphabets, finding that 6 letters are optimal for folding and that binding with partners is unavoidable with smaller alphabets, suggesting aggregation drove the evolution of a larger alphabet.
bioRxiv · May 25, 2018Biophysics