Microtubule-based mitotic spindles contain a micron-sized mixed-nucleotide zone
C. Castrogiovanni, A. V. Inchingolo, J. U. Harrison, D. Dudka, O. Sen, N. J. Burroughs, A. D. McAinsh, P. Meraldi
The paper reveals a mixed-nucleotide zone in mitotic spindle microtubules, between the GTP-cap and GDP-tubulin lattice, identified through HURP localization and computational simulation.
bioRxiv · Jul 23, 2021 · PreprintCell Biology