P. Meraldi

Transient lagging chromosomes cause primary microcephaly

This study shows that transient lagging chromosomes in anaphase, caused by loss of WDR62 and ASPM, lead to impaired cell proliferation and primary microcephaly through Aurora-B-dependent activation of 53BP1 and p21.

Centrosome age breaks spindle size symmetry even in symmetrically dividing cells

The paper shows that centrosome age causes subtle spindle asymmetry in symmetrically dividing cells, leading to unequal daughter cell sizes.

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

The paper shows mild replication stress causes premature centriole disengagement in G2 through ATR-Chk1 and subcritical Plk1 activity, disrupting DNA and centrosome cycle synchrony.

Microtubule-based mitotic spindles contain a micron-sized mixed-nucleotide zone

The paper reveals a mixed-nucleotide zone in mitotic spindle microtubules, between the GTP-cap and GDP-tubulin lattice, identified through HURP localization and computational simulation.

PLK1 controls centriole distal appendage formation and centrobin removal via independent pathways

The paper shows that PLK1 controls centrobin removal and distal appendage formation through separate pathways in human epithelial cells.

Centrosomes control kinetochore-fiber plus-end dynamics via HURP to ensure symmetric divisions

This study shows that centrosomes regulate k-fiber dynamics via HURP to ensure symmetric cell divisions by controlling k-fiber length and stability.