Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates
C. Chea, D.-Y. Lee, J. Kato, H. Ishiwata-Endo, J. Moss
This study identifies SARS-CoV-2 Mac1's ability to hydrolyze specific ADP-ribosylated substrates, revealing its role in disrupting host ADP-ribosylation pathways and potential as a therapeutic target.
bioRxiv · Feb 7, 2023 · PreprintBiochemistry