J. Kato

ADP-ribose-acceptor hydrolase 2 (Arh2) deficiency results in cardiac dysfunction, tumorigenesis, inflammation, and decreased survival

This study shows that Arh2 deficiency leads to cardiac dysfunction, tumorigenesis, inflammation, and reduced survival in mice.

Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates

This study identifies SARS-CoV-2 Mac1's ability to hydrolyze specific ADP-ribosylated substrates, revealing its role in disrupting host ADP-ribosylation pathways and potential as a therapeutic target.

Mono-ADP-ribosyltransferase 1 (Artc1)-deficiency decreases tumorigenesis, increases inflammation, decreases cardiac contractility, and reduces survival

Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging

This study shows that ketones like beta-hydroxybutyrate reduce premature aging features in Cockayne syndrome models by enhancing transcriptional readthrough of DNA secondary structures through histone acetylation.

FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.

This study shows FKBP13 is upregulated in interstitial lung diseases and correlates with disease severity, suggesting a protective role against fibrosis.

Exogenous Protein as an Environmental Stimuli of Biofilm Formation in Select Bacterial Strains

This study identifies exogenous protein as an environmental trigger for biofilm formation in several bacterial species, with species-specific optimal concentrations.