Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection.
A. Bergmann, K. Floyd, M. Key, C. Dameron, K. C. Rees, D. C. Whitehead, I. Hamza, Z. Dou
This study shows Toxoplasma gondii relies on its plant-like heme biosynthesis pathway for infection and demonstrates oxadiazon and its derivatives inhibit growth, suggesting heme biosynthesis as a therapeutic target.
PLOS Pathogens · May 14, 2020Peer-reviewedMicrobiology