RB1 loss triggers dependence on ESRRG in retinoblastoma
M. G. Field, J. N. Kuznetsoff, M. Zhang, J. J. Dollar, M. A. Durante, , Y. Sayegh, C. Decatur, S. Kurtenbach, D. Pelaez, J. W. Harbour
This study identifies ESRRG as a novel dependency in retinoblastoma cells following RB1 loss, showing its role in retinogenesis and oxygen metabolism and suggesting it as a therapeutic target.
bioRxiv · Dec 15, 2021Cancer Biology