M. Zhang

MG53 Protects Against Intestinal Inflammation by Inhibiting NLRP3 Inflammasome Activation

This study shows that MG53 reduces intestinal inflammation by inhibiting NLRP3 inflammasome activation in colitis models.

Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells

This study identifies a novel inflammation-associated dendritic cell state in human chronic inflammation and shows its spatial restriction and therapeutic relevance.

Microfluidic Droplet-Assisted Single-Cell Raman Sorting for High-Throughput Screening of Functional Lignin-Degrading Microbes

This paper introduces a microfluidic droplet-assisted single-cell Raman sorting system for high-throughput screening of lignin-degrading microbes, demonstrating its ability to identify active degraders with high accuracy.

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

Ventral Morphology and Ecological Implications of Cindarella eucalla (Artiopoda, Xandarellida) from Chengjiang Biota, China

This study reconstructs the morphology of Cindarella eucalla using X-ray computed tomography and fluorescent microscopy, revealing features that suggest it lived in muddy, light-filled environments and had escape capabilities.

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

PEPCy: Photostable fluoromodules for live cell, super-resolution microscopy of surface proteins

The paper introduces PEPCy, photostable fluoromodules that enhance cyanine dye photostability for live-cell super-resolution microscopy of surface proteins.

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport

This study investigates the brain distribution of remoxipride, showing that brain metabolism, not just BBB efflux, affects Kp,uu,BBB values less than 1.

The Microbiome and Metatranscriptome of a Panel from the Sarracenia Mapping Population Reveal Complex Assembly and Function Involving Host Influence.

This study analyzes the microbiome and metatranscriptome of Sarracenia species to reveal host-influenced community structure and functional convergence.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

A prostate cancer gastrointestinal transcriptional phenotype may be associated with diminished response to AR-targeted therapy

This study identifies a gastrointestinal gene expression phenotype in metastatic castration-resistant prostate cancer that correlates with reduced response to androgen receptor inhibitors.

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

This study identifies PDE1A as a promoter of NSCLC metastasis through interaction with YTHDF2 and activation of the STAT3 pathway.

Clostridium ablates tumors by degrading collagen mesh andinducing ferroptosis

This paper describes a Clostridium strain that degrades collagen and induces ferroptosis in tumors, leading to effective tumor destruction in mice.

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

Defect-Engineered Metal-Organic Frameworks as Nanocarriers for Pharmacotherapy: Insights into Intracellular Dynamics at The Single Particle Level

This study tracks single nanoMOFs in live cells to understand their intracellular dynamics and internalization pathways using fluorescence and machine learning.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

This study shows that TAK1 phosphorylates PLCE1 at S1060, reducing PIP2 hydrolysis and inhibiting esophageal squamous cancer metastasis.

Circular RNA HMGCS1 sponges miR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

This study identifies circHMGCS1 as a regulator of vascular endothelial dysfunction in diabetes by sponging miR4521, leading to impaired nitric oxide production and increased oxidative stress.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Suppressing APOE4-induced mortality and cellular damage by targeting VHL

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

The ZmHSF20-ZmHSF4-ZmCesA2 module regulates heat stress tolerance in maize

The paper identifies a regulatory module involving ZmHSF20, ZmHSF4, and ZmCesA2 that modulates heat stress tolerance in maize by balancing growth and defense mechanisms.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATION

This study shows that dopamine D4 receptor reduces NCC protein levels by promoting its ubiquitination and lysosomal degradation in mice.

Initial Characterization of Canine T-cell Receptor Repertoires Using RNA-seq Data from Different Diseases and Tissues

This study characterizes the canine T-cell receptor repertoire using RNA-seq data from various diseases and tissues, revealing similarities and differences with human TCR repertoires.

Elucidating the Role of Primary and Secondary Sphere Zn2+ Ligands in the Cyanobacterial CO2 Uptake Complex NDH-14: The Essentiality of Arginine in Zinc Coordination and Catalysis

This study investigates the role of specific amino acids in the cyanobacterial CO2 uptake complex NDH-14, focusing on their impact on Zn coordination and catalytic activity.