Conformational dynamics of C1r inhibitor proteins from Lyme disease and relapsing fever spirochetes
S. Roy, C. E. Booth, A. Powell-Pierce, A. M. Schulz, J. T. Skare, B. L. Garcia
This study reports the crystal structure of FbpC and uses molecular dynamics simulations to show conformational dynamics in borrelial C1r inhibitors, revealing structural plasticity in their anti-complement activity.
bioRxiv · Mar 1, 2023 · PreprintMicrobiology