S. Roy

Mechanism of host cell invasion by Leishmania through KMP-11 mediated cholesterol-transport and membrane phase transition

This paper identifies KMP-11 as a key Leishmania protein that mediates host cell invasion via cholesterol transport and membrane phase transition.

DGTS overproduced in seed plants is excluded from plastid membranes and promotes endomembrane expansion

This study shows that DGTS can be produced in seed plants and accumulates in endomembranes, promoting ER expansion without affecting growth or lipid remodeling.

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

A Multitrait Genome-Wide Association Study Reveals a Requirement for the Strigolactone Receptor DWARF14 in Optimal GOLVEN10 Signaling

This study identifies a genetic link between strigolactone signaling and GLV10 responsiveness in Medicago truncatula through genome-wide association and mutant analysis.

NMR structures of small molecules bound to a model of an RNA CUG repeat expansion

The paper reports NMR structures of small molecules bound to an RNA CUG repeat expansion motif, revealing binding interactions and conformational changes that inform drug design.

Spectrin condensates provide a nidus for assembling the periodic axonal structure

The paper shows spectrin condensates facilitate the formation of the periodic axonal structure by acting as local assembly hubs that later develop into a stable lattice.

Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

Identification of new markers of angiogenic sprouting using transcriptomics: New role for RND3

The paper identifies a 39-gene signature associated with endothelial cell sprout initiation and reveals a new role for RND3 in filopodial extension during angiogenesis.

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression

This study shows TEM4 regulates the cell cycle by controlling G1 progression through modulation of p21waf1/cip1 and cyclin B levels.

Novel roles for pirin proteins and a 2-ketoglutarate:ferredoxin oxidoreductase ortholog in Bacteroides fragilis central metabolism and comparison of metabolic mutants susceptibility to antimicrobials metronidazole and amixicile.

This study identifies pirin proteins and their interaction with metabolic enzymes in B. fragilis, showing their role in antimicrobial susceptibility to metronidazole and amixicile.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

An ab initio information-theoretic approach to proteins and protein-ligand interactions

The paper introduces a novel information-theoretic method to analyze protein conformational changes and their functional implications across different states.

Non-Electrostatic Basis for an Artificial Metalloenzyme Catalysis

This study identifies the catalytically active conformation of an artificial metalloenzyme through simulations and calculations, revealing non-electrostatic interactions that enable high catalytic efficiency.

Theileria annulata Infection Promotes p53 suppression, Genomic Instability and DNA deaminase APOBEC3H upregulation leading to cancer-like phenotype in host cells

This study identifies somatic mutations and genomic instability in Theileria annulata-infected leukocytes, linking them to cancer-like phenotypes through ROS1, TP53 suppression, and APOBEC3H upregulation.

Gut feeling: host and habitat as drivers of the microbiome in blackbuck (Antilope cervicapra)

This study identifies intrinsic and extrinsic factors shaping the gut microbiome of blackbuck across their range, finding host genetic diversity more influential than environmental factors.

Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias

The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.

E41K Mutation Activates Brutons Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate Dependent Invisible Dimer

The paper investigates the E41K mutation in BTK, showing it stabilizes an IP6-dependent PH-TH dimer, activating BTK independently of PIP3 binding.

Towards a phylogenomic classification of Magnoliidae

This study presents a comprehensive phylogenomic analysis of Magnoliidae, updating its classification by resolving previously ambiguous relationships and recognizing 21 families.

3-epicaryoptin induces G2/M phase cell cycle arrest and apoptosis in human breast cancer cells by disrupting the microtubule network, an in vitro and in silico investigation

This study investigates 3-epicaryoptin's anti-cancer effects on MCF-7 cells, showing it induces G2/M arrest and apoptosis by disrupting microtubules.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape of Neurodegenerative Disorders

This paper describes a protocol for isolating and lipidomic profiling of neuronal lipid droplets, revealing their unique lipid composition and potential role in neurodegenerative disorders.

A new genome-scale metabolic model of oleaginous microalgae with refined lipid metabolism elucidates Microchloropsis gaditana mutant phenotypes.

This paper presents a genome-scale metabolic model for Microchloropsis gaditana that captures lipid metabolism and mutant phenotypes, enhancing understanding of its metabolic capabilities.

Scaling of stochastic growth and division dynamics: A comparative study of individual rod-shaped cells in the Mother Machine and SChemostat platforms

The paper compares stochastic growth and division dynamics of bacterial cells in two microfluidic platforms, finding that mechanical confinement increases interdivision times but is compensated by division ratio adjustments.

KIF23 regulation by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma

Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion

This study identifies novel SIRT3 activators that restore catalytic activity under NAD+ depletion, offering potential therapeutic applications for age-related diseases.

Antimicrobial resistance in Arctic soils is mediated by competition and facilitation

The paper examines how antimicrobial resistance varies in Arctic soils and identifies competition and facilitation as key drivers of its spatial and temporal spread.

High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography

This paper develops a DNA origami cryptography protocol using high-speed 3D DNA-PAINT and unsupervised clustering to enhance encryption key size and information retrieval accuracy.

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering

This study identifies ligand-induced segregation of phosphatases CD45 and CD148 from {gamma}{delta} TCRs as essential for TCR triggering by nonclassical MHC class Ib antigens.

Circadian proteomics reveal rampant tuning of post-transcriptional apparatus by Chlamydomonas clock

The paper quantifies the Chlamydomonas proteome over two circadian cycles, revealing that post-transcriptional processes, not mRNA oscillations, drive most protein rhythms.

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.