Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae
I. Prada-Luengo, H. D. Moller, R. A. Henriksen, Q. Gao, C. E. Larsen, S. Alizadeh, L. Maretty, J. Houseley, B. Regenberg
This study shows that replicative aging in yeast leads to loss of genetic heterogeneity from extrachromosomal circular DNA, with rDNA circles dominating in aged cells.
bioRxiv · Feb 11, 2020Cell Biology